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ea0032p655 | Male reproduction | ECE2013

Fat boosts, while androgen receptor activation counteracts, BPH-associated prostate inflammation

Vignozzi Linda , Gacci Mauro , Cellai Ilaria , Santi Raffaella , Corona Giovanni , Morelli Annamaria , Rastrelli Giulia , Comeglio Paolo , Sebastianelli Arcangelo , Maneschi Elena , Nesi Gabriella , De Nunzio Cosimo , Tubaro Andrea , Mannucci Edoardo , Carini Marco , Maggi Mario

Background: Metabolic syndrome (MetS) and benign prostate hyperplasia (BPH) are often comorbid. Chronic inflammation, a determinant pathogenic factor for BPH, is a putative link between the two conditions.Methods: In a multi-center cohort of BPH patients (n=244) who underwent prostatectomy, we evaluated whether MetS is associated with prostatic inflammation in BPH specimens. In addition, we investigated the in vitro inflammatory effects...

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Fat boosts, while androgen receptor activation counteracts, BPH-associated prostate inflammation

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